Studies on carcinogen metabolizing enzymes in the rainbow trout
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Studies on carcinogen metabolizing enzymes in the rainbow trout

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Published .
Written in English


  • Cytochrome P-450.,
  • Nitrosoamines -- Toxicology.,
  • Rainbow trout -- Diseases.,
  • Carcinogenesis.,
  • Liver -- Diseases.

Book details:

Edition Notes

Statementby Shiu-Ling Chen.
The Physical Object
Pagination77 leaves, bound :
Number of Pages77
ID Numbers
Open LibraryOL15184973M

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Characterization and induction of xenobiotic metabolizing enzyme activities in a primary culture of rainbow trout hepatocytes Article (PDF Available) in Xenobiotica 21(4) May with. STUDIES ON THE DIGESTIVE ENZYMES OF RAINBOW TROUT-I The enzymatic actions of the extracts from the digestive organs were investigated on various growth stages of rainbow trout for the purpose of obtaining some useful knowledge on the culture of the fish. and even at a lower temperature (at 5°C) the enzymes did not lose most of their. The disposition of naphthalene and its metabolites in the brain of rainbow trout (Salmo gairdneri) Tracy K. Collier, Margaret M. Krahn, Donald C. Malins Pages This study was designed to assess the effects of dietary carotenoid supplementation on liver and kidney xenobiotic-metabolizing enzymes in the rainbow trout.

  SUMMARY Carcinoma of the urinary bladder is the most common malignancy in the Middle East and parts of Africa where schistosomiasis is a widespread problem. Much evidence supports the association between schistosomiasis and bladder cancer: this includes the geographical correlation between the two conditions, the distinctive patterns of gender and age at diagnosis, the Cited by: Duplicate lots of rainbow trout (Salmo gairdneri) were fed either control diet (CD) or ppm Aroclor (a polychlorinated biphenyl—PCB) for 3 mth followed by initiation of liver carcinomas with 20 ppb dietary aflatoxin B 1 (AFB 1) for 2 8 and 12 mth after AFB 1 treatment, fish were sampled and tumor incidence determined. Trout that were prefed PCB showed a 45% inhibition in Cited by: Phase I and II metabolizing enzyme The cytochrome P are phase I drug metabolizing enzymes Catalyze hydroxylation/oxidation of many organic substances and drugs Can converts pro-carcinogens to carcinogens Phase I enzymes trigger phase II enzyme like glutathione s transferase Coverts phase I products to more hydrophilic moieties. Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other a toxicant enters an organism, it can interact with these receptors and produce structural or.

Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Immunochemical approaches to studies of CYP1A localization and induction by xenobiotics in fish. Authors; Ingebrigtsen, K., Skaare, J.U. and Goksoyr, A. () Response of hepatic xenobiotic metabolizing enzymes in rainbow trout (Oncorhynchus mykiss) and cod (Gadus morhua) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD Cited by:   Rainbow trout fed ppm dibenzo(a,l)pyrene (DBP, found in tobacco smoke and other combustion products), developed tumors in the liver (%) and stomach (%). Animals receiving ppm CHL mixed into the DBP diet developed markedly lower tumor response in liver (%) and stomach (%).   Induction of three drug-metabolizing enzymes occurred in liver microsomes of mice and rats kept on softwood bedding of either red cedar, white pine, or ponderosa pine. This induction was reversed when animals were placed on hardwood bedding composed of a mixture of beech, birch, and maple. Differences in the capacity of various beddings to induce may partially explain divergent Cited by: